- Discovery of mechanism by which a cytosolic chaperonin is a potent regulatory hub that gates insulin secretion.
- Discovery of the mechanism by which a beta-cell transcription factor, Zfp148, regulates insulin secretion
- Discovery of the mechanism by which a novel lnc-RNA regulates the clearance of insulin from the circulation
- Identification of genes that account for high heterogeneity in the metabolic response to diets.
Training Environment
Trainees in the laboratory work at the interface of genetics, metabolism, physiology, and computational biology.
Projects provide opportunities to learn:
• Mouse genetics and genome-wide mapping
• Metabolomics and stable-isotope tracing
• Pancreatic islet biology
• Diabetes physiology
• Bioinformatics and systems genetics
• Molecular and cellular biology
Our goal is not only to answer important biological questions, but also to train scientists who can bridge disciplines and pursue independent, innovative research careers.